The Next Big Thing in Preventive & Personalized Health in 2025 Will Be...
15 of the brightest minds in longevity, preventive and personalized health weight in.
A happy and healthy 2025 to you all!
Last week, I had lunch with my 98-year-old grandfather at his nursing home to celebrate the new year. Longevity genes run strong in my family – at 98, he remains sharp as ever, making jokes and telling me WW2 stories. As I looked around at the fifty other nursing home residents, most in vegetative states, I had a striking realization: this isn't how aging will look in ten years. We're living through a moment where medical advances are about to fundamentally transform the aging process and how we'll look, think, and feel at 80, 90…and beyond.
The signs of the preventative health revolution are everywhere at this start of the year: from Netflix's launch of “Don't Die" (the documentary following controversial tech entrepreneur Bryan Johnson's $2M/year quest to reduce his biological age), to RFK’s impending war on ultra-processed foods, the U.S. Surgeon General’s recent advisory linking alcohol to cancer risk, or the emerging research on GLP-1s' potentially transformative impact on everything from metabolic health to neurodegeneration. 2025 promises to be yet a watershed year for preventive and personalized medicine.
In this special edition, I have gathered insights from 15 of the most respected experts in preventative medicine, personalized health, and longevity to share their visions for 2025. (Credit where it's due: this format is inspired by Nikhil Basu's excellent "the next big thing"yearly newsletter which explores broader tech trends).
Thank you to Tom Latkovic, Nikolina Lauc, Sebastian Brunemeier, Phil Newman, Jean-Charles Samuelian-Werve, Michael Geer, Jean Daniel Malan, Christina Farr, Jonathan Swerdlin, Anant Vinjamoori M.D., Sunita Mohanty, Yuta Lee, Jacob Peters, Paul Grewal M.D., and Marc Serota M.D. for their trust and contribution!
…Consumer Health Ownership
Far more focus than ever before about wellness and preventative health, even as the U.S. healthcare system remains focused on "sick care" versus "health care." The cultural zeitgeist is shifting to be more focused on toxins In the home (forever chemicals, etc.), the negative impacts of soda, alcohol, and processed foods; as well as the downsides to our sedentary lifestyles. We've been talking about this shift for a long time -- but I don't believe the system will drive it, as much as we'll see it in the realm of health and wellness influencers. There will be "snake oil" products that emerge, but also a shift towards more healthy behaviors - so I hope we'll react to this trend with the nuance it deserves.
Christina Farr - CEO, Second Opinion Media, Investor & Co-founder, Scrub Capital
The next big thing in 2025–and beyond— will be individuals owning their health. Proactive and comprehensive lab testing & imaging will be the standard.
Jonathan Swerdlin - Co-Founder & CEO, Function Health
…Longevity Biotech
The next big things in LongBio for 2025 will be muscle preserving drugs, AMPK activators, rapamycin analogs, non-viral gene therapy vectors, special subtypes of mesenchymal stem cells, and stem cell secretome/exosomes. IVF embryo selection will also become noticed. Longer term, the most powerful geroprotective therapies will be gene and cell therapies.
Sebastian Brunemeier - CEO & Founder, ImmunAGE Bio and Founder, Healthspan Capital
We're on the cusp of a significant shift in the longevity sector. I anticipate a surge in funding for longevity technologies, particularly as Decentralized Science (DeSci) projects in the crypto space evolve into DAOs. This trend is likely to gain momentum, especially with the recent success of organizations like VitaDAO, which closed a $4.1 million fundraising round from strategic contributors including Pfizer Ventures, and more recently Binance Labs which is investing in longevity research and emerging health challenges through its investment in BIO Protocol.
Phil Newman - CEO & Founder, Longevity.technology
…LLMs
The next big thing in 2025 will be the creation and leveraging of open Large Biological Models (similar to LLMs but trained on biological and intervention/treatment data) to enable companies and researchers with even small health datasets to make highly predictive life saving health models - and start to finally deliver personalized health services.
Michael Geer - Co-Founder, Humanity
I believe the application of transformer LLMs trained on extensive multiomic datasets, both existing and synthetic, will significantly accelerate discoveries in drug repurposing. This could lead to the identification of novel compounds and, most importantly, facilitate disease prediction, paving the way for the adoption of precision medicine preventative measures. If the question was over 5 years I would have mentioned Il11 antibodies, senolytics, exosomes, stem cell reprogramming, gene therapy targeting telomerase, follistatin and alzheimer, but these all have to run their courses through FDA approval to be impactful.
Jean Daniel Malan - Longevity Angel Investor
…AI-Enabled Healthcare
The next big thing in 2025 will be the fundamental transformation of our relationship with healthcare through AI, similar to how digital maps revolutionized navigation. Instead of the current model of 2 medical interactions per year, people will have daily/weekly health interactions through specialized multimodal medical AIs that provide zero-friction access to expert knowledge, proactive engagement, and personalized preventive care guidance, with no taboo.
Jean Charles Samuelian-Werve - Co-Founder & CEO, Alan Health
The next big thing in 2025 will be superhuman doctors, powered by AI and not replaced with AI. As the data exhaust of an individual patient continues to explode, and more doctors embrace personalized medicine, AI will actually help doctors deliver more human-centered care and massively increase individual clinician capacity.
Sunita Mohanty - Founder & CEO, Vibrant
…Brain Health
The next big thing in 2025 will be recognition that whole body-health is brain health.
A growing body of evidence shows that the health of the body and the brain are deeply interconnected. Muscular strength, balanced hormones, a strong heart, stable blood sugar, and robust immunity all contribute to sharper cognitive performance now and significantly reduce the risk of dementia or Alzheimer’s in the future.
This shift means that to prevent dementia we must prioritize empowering people to proactively optimize their health in these areas—before symptoms arise—rather than simply treating issues after they appear.
Tom Latkovic - Co-Founder & CEO, BetterBrain
In 2025, we’ll see a growing recognition of psychoneuroimmunology (PNI)—the study of how the mind and immune system are intricately connected. Research is increasingly showing that emotional trauma, chronic stress, and unresolved psychological issues can accelerate aging, increase disease risk, and shorten lifespan—sometimes more profoundly than physical factors like menopause. This year marks a turning point as we begin to fully understand the profound interplay between mental health and physical well-being, paving the way for therapies that treat the whole person.
Nikolina Lauc - Co-Founder & CEO, GlycanAge
…Entreprise
Personalized medicine and longevity-focused healthcare will increasingly be offered as employee benefits by enterprises. While this trend won’t become fully mainstream in 2025, we’ll see more companies adopting it as a way to provide access to this increasingly desire approach to health. Organizations like Atria are already leading the way, and I believe this approach will ultimately shape how most people experience personalized and preventative medicine in the future.
Anant Vinjamoori - President, Next Generation Medicine. Longevity Chief Officer, Superpower. Head of Longevity Medicine, Midi Health
…Wearables
AI-driven wearables will dominate health tech in 2025, expanding beyond current heart rate, sleep, and glucose tracking to include advanced metrics like blood pressure, circadian rhythm disruption, and biological age acceleration. This evolution will accelerate the future adoption of longevity-focused metrics such as NAD (cell health and metabolism) and GDF15 (inflammation), embodying the principle “we focus on what we measure” in personal health management. The exponential growth in continuous measurable health data through wearables marks the beginning of a revolution in proactive health monitoring.
Yuta Lee - Founder & CEO, Accelerated Biosciences
…Real, Nutritional Foods
I think that one of the next big things will be nutrient density. People are going to start caring about how high quality the nutrients are in their food. It's not just enough to eat healthy and organic, which is often pesticide free - they'll want to eat the strawberry that has 10 times more nutrients because it was grown in higher quality less nutrient depleted soil, the steak that has 10x more nutrients, or the protein powder from the cow that was fed much higher quality food and therefore is more nutrient-dense. I think nutrient density is going to be a massive trend.
Jacob Peters - Co-founder & CEO, Superpower
While technological advancement continues at an exciting clip, the accelerating trend I’m seeing year over year is that access to high quality, untainted, unprocessed food is fast becoming the ultimate luxury. Our DNA knows how to thrive when it is not actively interfered with–but pollution, microplastics, petrochemicals, endocrine disruptors, even endogenous harm from elevated stress levels and the demands of modern life all detract far more from our lifespan and healthspan than any IV drip or biometric data will augment. I think farmshares and country living are going to come back in a big way!
Paul Grewal MD. - Founder & CEO, Curia Health & Co-author of NY Times Best-Seller Genius Foods
...GLP1s
The next big thing in 2025 will be sustaining a healthy weight using low dose GLP1 combined with behavioral and lifestyle changes. GLP1's have been relegated to patients that are classified as having a disease (obese or overweight) but I think we will see GLP1 treatment shift to maintaining a healthy weight, curbing appetite, reducing inflammation and other valuable benefits to healthy patients.
Marc Serota M.D. - Founder & CEO, MD Integrations
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